"Stacking" or "Picking" Patents? The Inventors' Choice Between Quantity and Quality

This paper studies the determinants of the quantity and quality of inventors’ patents. It uses a sample of 793 inventors drawn from the PatVal-EU dataset and the information on EPO patents that they contributed to inventing during the period 1988-1998. It explores three aspects of the inventors’ productivity: 1) the number of EPO patents that they produce; 2) their average quality; 3) the quality of the most valuable patents. By jointly estimating the three equations we find that the inventors’ level of education, employment in a large firm and involvement in large-scale research projects positively affect quantity. Yet, apart from the size of the research project, none of these factors directly influences the expected quality of the innovations. They do, however, indirectly, as we find that the number of innovations explains the probability of producing a technological hit (the maximum value). Also, there are no decreasing returns in the innovation process at an individual level, as the number of innovations that an inventor produces is not correlated with their average quality.Productivity, Industrial inventors, Patent quality

Healthcare in Italy: expenditure determinants and regional differentials

The aim of this work is to identify the determinants of health spending differentials among Italian regions, which could highlight the existence of potential margins for savings. The analysis exploits a dataset for the panel of the 21 Italian regions starting in the early 1990s and ending in 2006. After having controlled for standard healthcare demand indicators, spending differentials appear to be associated with differences in the degree of appropriateness of the treatments, supply structure and social capital indicators. These results suggest that savings could be achieved without reducing the amount of services supplied to citizens. This is particularly important in view of the expected rise in health spending associated with the forecast demographic developments.government expenditure, health, regional variation

Nonlinear dynamics in welfare and the evolution of world inequality

The paper proposes a measure of countries' welfare based on individuals' lifetime utility and applies it to a large sample of countries in the period 1960-2000. Even though welfare inequality across countries appeared stable, the distribution dynamics points out the emergence of three clusters. Such tendencies to polarization shall strengthen in the future. In terms of the world population distribution, welfare inequality decreased as the result of the decline in inequality of both per capita GDP and life expectancy, but this downward trend should be reverted hereafter. Finally, a polarization pattern emerged, which is expected to further intensify in the future.distribution of welfare, nonparametric estimation, polarization, distribution dynamics, inequality

Understanding Inappropriateness in Health Care. The Role of Supply Structure, Pricing Policies and Political Institutions in Caesarean Deliveries

The upward trend in the incidence of caesarean deliveries is a widespread stylised fact in many countries. Several studies have argued that it does not reflect, at least in part, patients’ needs but that it is also influenced by other factors, such as providers/physicians incentives. Not surprisingly, the incidence of caesarean sections is often used as an indicator of the degree of (in)appropriateness in health care, which has also been found to be strongly correlated with excessive expenditure levels. In this paper, we exploit the significant regional variation in the share of caesarean sections recorded in Italy to explore the impact on inappropriateness of three groups of variables: 1) structural supply indicators (e.g., the incidence of private providers); 2) pricing policies (role of DRG tariffs); 3) political economy indicators (to capture different approaches to the governance of the health care sector). The analysis controls for demand side factors, such as the demographic structure of the population and education levels. The results suggest that DRG tariffs might be an effective policy tool to control inappropriateness, once the composition of the regional health care system – in terms of private vs. public providers – is taken into account. Also some characteristics of regional governments and the funding sources of regional health spending do matter.health care, inappropriateness, regional disparities, pricing policy, political economy

Understanding Inappropriateness in Health Care: The Role of Supply Structure, Pricing Policies and Political Institutions in Caesarean Deliveries

The upward trend in the incidence of caesarean deliveries is a widespread stylised fact in many countries. Several studies have argued that it does not reflect, at least in part, patients’ needs but that it is also influenced by other factors, such as providers/physicians incentives. Not surprisingly, the incidence of caesarean sections is often used as an indicator of the degree of (in)appropriateness in health care delivery, which has also been found to be strongly correlated with expenditure differentials between regions. We exploit the significant regional variation in the share of caesarean deliveries in Italy to explore the impact on inappropriateness of three groups of policy variables: 1) political economy indicators (as a way to capture different approaches to the governance of the health care sector); 2) reimbursement and pricing policies (as DRG fees); 3) structural supply indicators (such as the incidence of private providers and the number of employees). The analysis controls for the demographic characteristics of patients and their education levels. Results suggest that tariffs might be an effective policy tool to control inappropriateness; however, the structure of the regional health care system matters. More importantly, also some characteristics of the regional governments and the financing mechanisms play a role.

Expression and localization of Phosphoinositide-specific Phospholipases C in cultured, differentiating and stimulated human osteoblasts

The osteoblasts contribute to bone homeostasis maintaining the bone mass, and intervene in bone injuries repair. The limited number of available therapeutic agents promoting osteogenesis aroused the greatest interest in the control of osteoblasts’ activity. Insights in the events leading to the proliferation and differentiation of osteoblasts might allow uncover potential molecular targets to control the complex mechanisms underlying bone remodeling. Oscillations of calcium act crucially during this remodeling, affecting both the differentiation and proliferation of osteoblasts. Signal transduction pathways contribute to the differentiation and metabolic activities of osteoblasts, with special regard to calcium-related signaling, including the Phosphoinositide (PI) pathway and related Phospholipases C (PLCs). In order to evaluate the role of PLC enzymes’ family in human osteoblasts (HOBs), we analyzed the expression of PLC genes and the localization of PLC enzymes in cultured HOBs and in in vitro differentiating HOBs after 3, 10, 17 and 23 days, and in HOBs stimulated with Lipopolysaccharide, which affects the differentiation of osteoblasts, after 3, 6, 24 and 48 hours. Our results confirm the transcription of most PLC genes and the presence of a number of PLC enzymes in HOBs, differently localized in the nucleus, in the cytoplasm or both, as well as in cell protrusions. The localization of PLC enzymes within the cell suggests the activation of both the PI nuclear and of the cytoplasmic cycle in HOBs. Depending on the experimental conditions, transcripts of splicing variants of selected PLC genes were detected and the localization of most PLC enzymes varied, with special regard to enzymes belonging to the PLC , and sub-families. Further studies addressed to elucidate the complex network involving the signal transduction of PLCs might provide further insights into the complex signal transduction network in bone remodeling, also offering the opportunity to identify promising molecular targets

Everything you Always Wanted to Know about Inventors (but Never Asked): Evidence from the PatVal-EU Survey

By drawing information from a survey of inventors of 9,017 European patents (PatVal-EU), this paper provides novel and detailed data about the characteristics of the European inventors, the sources of their knowledge, the importance of formal and informal collaborations among researchers and institutions, the motivations to invent, and the actual use and economic value of the patents. This is important information as the unavailability of direct indicators has limited the scope and depth of the empirical studies on innovation.